Trazodone is an antidepressant. It is a serotonin antagonist/reuptake inhibitor which increases the activity of serotonin in the central nervous system given by mouth.

Trazodone is used to reduce anxiety in order to modify or manage unwanted behaviors such as phobias, fears and separation anxiety.

May be used to assist with restricting activity and cage rest following an orthopedic procedure or surgery.

• Has experienced side effects on other drugs/products
  has experienced digestive upset now or ever
• Has experienced liver or kidney disease now or ever
• Has experienced any other medical problems or allergies now or ever
• Is nursing
• Is receiving monoamine oxidase inhibitors
• Requires full alertness when performing – guide dogs, police dogs, rescue dogs
• Has a known hypersensitivity or allergy to this drug should not take this medication
• Is on any other medicines or supplements other than heartworm preventative and flea and tick preventative, including those you can get without a prescription.

Safety in pregnant or nursing pets has not been established.

Read and follow the prescription label carefully.

Give the exact amount prescribed and only as often as directed.

It may require several days or weeks to determine efficacy of this medication.

Trazodone can be given with or without food.

Baseline blood work may be recommended to assess your pet’s general health before starting this medication.

Periodic blood work to monitor its effects on the body may also be advised if long term therapy is necessary. Dose adjustments may be made based upon these results and an assessment of how your dog is responding clinically.

This medication will take effect quickly, in about 1 to 2 hours. Improvement in clinical signs should follow.

Ideally, give this medication at the same time(s) daily.

If a dose is missed and your dog is too active, give it as soon as you can. If it is time already for the next dose, skip the missed dose and go back to the normal schedule. Do not give two doses at the same time.

Trazodone should be stored in a childproof container in a cool, dry place at room temperature away from heat and direct sunlight.

Keep this and all medication out of reach of children and pets.

Call your physician immediately if you accidentally take this product.

This medication has fewer adverse effects than tricyclic antidepressants.

This medication can affect the central nervous system causing sedation, lethargy, incoordination, increased anxiety and aggression.

This medication can affect the gastrointestinal system causing an increase in appetite, vomiting and diarrhea.

If you notice any of these symptoms or if your pet’s condition worsens contact your veterinarian.

This short-acting medication should stop working within 24 hours, although effects may last longer in pets with liver or kidney disease.

Yes, but possible interactions may occur when giving Trazodone in conjunction with aspirin, azole antifungals (e.g. ketoconazole, fluconazole), blood pressure medications, central nervous system depressants, digoxin, macrolide antibiotics (e.g. erythromycin, clarithromycin), metoclopramide, monoamine oxidase inhibitors, NSAIDs, phenothiazines, selective serotonin reuptake inhibitors (e.g. fluoxetine).

If Trazodone is used with other serotonergic drugs, there is increased risk for serotonin syndrome: vomiting, diarrhea, seizures, hyperthermia, depression, dilated pupils, vocalization, death, blindness, increased salivation, difficulty breathing, incoordination and coma.

Drugs other than those listed may also interact with Trazodone.

If your pet experiences any unusual reactions when taking multiple medications, contact your veterinarian.

Contact your veterinarian immediately if your pet receives more than the prescribed amount.

Notify your veterinarian if your animal’s condition does not improve or worsens despite this treatment.

As with all prescribed medicines, Trazodone should only be given to the pet for which it was prescribed. It should be given only for the condition for which it was prescribed.